Behavioral and Integrative Treatment Development Program (R01)

(PA-10-012)
National Institute on Drug Abuse
National Institute on Alcohol Abuse and Alcoholism
National Institute of Nursing Research
Application Receipt/Submission Date(s): Multiple dates, see announcement.

The purpose of this FOA for R01 applications is to encourage Stage II or Stage III research to conduct clinical trials, examine mechanisms of behavior change, determine dose-response, optimize combinations, and/or ascertain best sequencing of behavioral, combined, sequential, or integrated behavioral and pharmacological (1) drug abuse treatment interventions, including interventions for patients with comorbidities, in diverse settings; (2) interventions to prevent the acquisition or transmission of HIV infection among individuals in drug abuse treatment; (3) interventions to promote adherence to drug abuse treatment, HIV and addiction medications; and (4) interventions to treat chronic pain.

Stage I involves research on the development, manualization, refinement, improvement, adaptation, and pilot testing of behavioral and integrative treatment, HIV prevention, and therapist training interventions. Stage I may include translational studies involving research from other disciplines (e.g. basic science or neuroscience) conducted or utilized to gain information about mechanisms of behavior change and ultimately to develop new or improved interventions.  Stage I may also include “community-friendly” research to adapt interventions that retain or increase their potency when modified for use in real-world settings.
Stage II includes larger-scale clinical trials or dose-response studies of piloted interventions that show promise.  Of particular interest are studies that examine mechanisms of behavior change within the context of treatment research.  

Stage III encompasses research aimed at ensuring that evidence-based interventions retain their effects in community settings (e.g., ERs, primary care, criminal justice settings, etc.).   Stage III includes studies that examine whether interventions retain their efficacy when administered by community therapists..  Stage III may also include studies that test training methods for community providers to administer evidence-based interventions.