Research Summary:Darryl Holman is an Associate Professor in the Department of Anthropology (Biocultural program), and an affiliate of CSDE and the Center for Statistics and the Social Sciences. His research lies at the intersection of biological anthropology and population studies, integrating traditional microdemographic methods with biomarker and statistical models of biocultural processes (Holman 2000b). His research on age-specific total fecundability and total fetal loss in Bangladeshi women (Holman et al. 1998, 2000; Holman and Wood in press) establish that total fecundability is constant across most of the reproductive lifespan, and that the observed age-related decline in apparent fecundability results from an increase in early pregnancy loss. Holman developed a biostatistical model of follicular depletion, which has been used for understanding female reproductive senescence (O'Connor et al. 1998; Holman et al. in press a), the biology of the menopause, the perimenopausal transition (O'Connor et al. 2001a), and the evolution of reproductive senescence (Wood et al. in press b). Holman has been studying aspects of child health in non-industrial settings, including determinants of the timing to breastfeeding (Holman and Grimes 2001) and the growth and development of children (Holman and Jones 1998; Konigsberg and Holman 1999). His research in historical demography and paleodemography is aimed at understanding health and mortality in past populations. He has developed new statistical methods for estimating age-at-death distributions from imperfect age indicators (Holman et al. in press b; Konigsberg and Holman 1999), and recovering population growth rates from paleodemographic observations (Wood et al. in press a).
Recent Publications:- Holman, D. J.; O'Connor, K. A.; Jones, R. E., (Forthcoming), Assessing biological mortality bias in deciduous tooth emergence, American Journal of Physical Anthropology.
- O’Connor, K.; Ferrell, R.; Brindle, E.; Shofer, J.; Trumble, B.; Holman, D.; Weinstein, M., (Forthcoming), Progesterone and ovulation across stages of the transition to menopause, Menopause.
- O'Connor, K. A.; Ferrell, R. J.; Brindle, E.; Shofer, J.; Holman, D. J.; Miller, R. C.; Schechter, D. E.; Singer, B.; Weinstein, M., (2009), Total and Unopposed Estrogen Exposure across Stages of the Transition to Menopause, Cancer Epidemiol Biomarkers Prev, 3: 18, 828-836.
- Ferrell, R.; O'Connor, K.; Holman, D.; Brindle, E.; Miller, R.; Rodriguez, G.; Simon, J.; Mansfield, P.; Wood, J.; Weinstein, M., (2007), Monitoring reproductive aging in a 5-year prospective study: aggregate and individual changes in luteinizing hormone and follicle-stimulating hormone with age, Menopause, 14: 1, 29.
- Ferrell, R. J.; O’Connor, K. A.; Rodriguez, G.; Holman, D. J.; Brindle, E.; Miller, R. C.; Simon, J.; Mansfield, P. K.; Wood, J. W.; Weinstein, M., (2007), Monitoring reproductive aging in a 5-year prospective study: aggregate and individual changes in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) with age, Menopause, 14: 1, 29-37.
- Ferrell, R. J.; O'Connor, K. A.; Holman, D. J.; Simon, J. A.; Pincus, S. M.; Rodriguez, G.; Weinstein, M., (2006), The length of perimenopausal menstrual cycles increases later and to a greater degree than previously reported, Fertility and Sterility, 86: 3, 619.
- Holman, D. J.; Grimes, M. A.; Achterberg, J. T.; Brindle, E.; O'Connor, K. A., (2006), Distribution of postpartum amenorrhea in rural Bangladeshi women, American journal of physical anthropology., 129: 4, 609.
- Holman, D. J.; O'Connor, K. A.; Wood, J. W., (2006), Age and female reproductive function: Identifying the most important biological determinants, Age: Human Clock and Scale of Social Organization, Hill, A.; Mascie-Taylor, N.; Sauvain-Dudgeril, C., Oxford University Press, Oxford.
- O'Connor, K. A.; Holman, D. J.; Brindle, E.; Miller, R. C.; Shofer, J. B.; Ferrell, R. J.; Klein, N. A.; Soules, M. R.; Mansfield, P. K.; Wood, J. W., (2006), Ovulation detection methods for urinary hormones: precision, daily and intermittent sampling and a combined hierarchical method, Human Reproduction, 21: 6, 1442-1452.
- Ferrell, R. J.; O'Connor, K. A.; Rodriguez, G.; Gorrindo, T.; Holman, D. J.; Brindle, E.; Miller, R. C.; Schechter, D. E.; Korshalla, L.; Simon, J. A.; Mansfield, P. K.; Wood, J. W.; Weinstein, M., (2005), Monitoring reproductive aging in a five year prospective study: Aggregate and individual changes in steroid hormones and menstrual cycle lengths with age, Menopause, 12: 5, 567-577.
- Holman, D. J.; Yamaguchi, K., (2005), Longitudinal analysis of deciduous tooth emergence: IV. Covariate effects in Japanese children, American Journal of Physical Anthropology, 126, 352-358.
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Ph.D. 1996, Pennsylvania State University. Biodemography, natural fertility, mortality, anthropological demography, human population biology, Bangladesh.
