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Fohner and Colleagues Identify Potential Biomarkers for Brain Aging

Posted: 11/29/2023 (CSDE Research)

CSDE Affiliate Dr. Alison Fohner (Epidemiology) and co-authors released research in the Journal of Alzheimer’s Disease, titled “Proteome Network Analysis Identifies Potential Biomarkers for Brain Aging“. Alzheimer’s disease and related dementias (ADRD) involve biological processes that begin years to decades before onset of clinical symptoms. The plasma proteome can offer insight into brain aging and risk of incident dementia among cognitively healthy adults. This study sought to identify biomarkers and biological pathways associated with neuroimaging measures and incident dementia in two large community-based cohorts by applying a correlation-based network analysis to the plasma proteome. Although associations from the discovery cohort did not replicate, proteome networks can help identify biological pathways in preclinical brain atrophy.

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