Article Published by John-Stewart and Co-authors on Medication for Children Living with HIV
Posted: 10/5/2023 (CSDE Research)
CSDE Affiliate Grace John-Stewart (Global Health, Epidemiology, Medicine, and Pediatrics) and co-authors recently published their research, “Biomarker-confirmed suboptimal adherence to isoniazid preventive therapy among children living with HIV in western Kenya” in AIDS. Their study primarily sought to assess the level and correlates of biomarker-confirmed adherence to isoniazid (INH) preventive therapy (IPT) among children living with HIV (CLHIV). Adherence was assessed by pill counts or caregiver- or self-reports, and urine biomarkers (in-house dipstick and IsoscreenTM©). Both urine biomarker tests detect INH metabolites within 48 hours of ingestion. Consistent adherence was defined as having positive results on either biomarker at all visits. Correlates of biomarker-confirmed nonadherence at each visit were evaluated using generalized estimating equations. The in-house dipstick was validated using IsoscreenTM© as the reference. Biomarker-confirmed adherence to IPT was sub-optimal and was associated with viral non-suppression and duration of IPT. Urine dipstick testing may be useful in assessing adherence to IPT in clinical care.